Pada penderita penyakit ginjal kronis (PGK) terjadi retensi fosfat yang berakibat pada peningkatan kadar hormon parartiroid intak. Kadar hormon paratiroid intak yang tinggi dikaitkan dengan kualitas hidup yang rendah pada penderita PGK yang menjalani hemodialisis. Kalsium karbonat secara signifikan menurunkan kadar fosfat sehingga dapat menurunkan kadar hormon paratiroid intak. Penelitian ini bertujuan untuk mengetahui hubungan kadar hormon paratiroid intak dengan kualitas hidup pasien hemodialisis yang diberikan kalsium karbonat. Penelitian cross sectional terhadap pasien hemodialisis rutin di RS Akademik UGM Yogyakarta dilakukan pada bulan Maret-April 2014. Penilaian kualitas hidup menggunakan kuesioner KDQOL-SF versi 1.3 dan pengukuran kadar hormon paratiroid intak dilakukan saat penelitian berlangsung. Subyek penelitian terdiri dari 15 pasien pria (62,5%) dan 9 pasien wanita (37,5%). Usia rata-rata 49,4±11,46 tahun. Rata-rata lama menjalani hemodialisis 15,7(3,0- 120,0) bulan. Kadar hormon paratiroid intak rata-rata sebesar 459,5 (8,0-3034,0) pg/mL. Skor rata-rata kualitas hidup untuk domain kesehatan fisik 53,8 ± 10,1; domain kesehatan mental 58,6 ± 12,7; domain penyakit ginjal 69,3 ± 9,8 dan domain kepuasan pasien 68,8 ± 8,1. Hasil analisis dengan korelasi Spearman menunjukkan bahwa kadar hormon paratiroid intak berpengaruh secara bermakna dengan domain kesehatan fisik (p≤0,05), khususnya pada parameter fungsi fisik dan persepsi kesehatan umum. Kadar hormon paratiroid intak tidak berpengaruh secara bermakna dengan domain kesehatan mental, penyakit ginjal, dan kepuasan pasien (p>0,05).

In patients with chronic kidney disease (CKD) occurs phosphate retention resulting in increased levels of the hormone parartiroid intact. Intact parathyroid hormone levels were associated with lower quality of life in patients with CKD undergoing hemodialysis. Calcium carbonate significantly lowers phosphate levels in order to reduce levels of intact parathyroid hormone. This study aims to determine the correlation between intact parathyroid hormone levels with quality of life in hemodialysis patients given calcium carbonate. Cross-sectional research on regular hemodialysis patients at the RS Akademik UGM conducted in March-April 2014. Assessment of quality of life using KDQOL-SF version 1.3 questionnaire and measurement of intact parathyroid hormone levels done during the study. The study subjects consisted of 15 male patients (62.5%) and 9 women (37.5%). Average age was 49.4±11.46 years. The average length of undergoing hemodialysis was 23.2±15.61 month. Average intact parathyroid hormone levels was 459.5±596.8 pg/mL. The mean score for quality of life in physical health domains was 53.8±10.1; mental health domains was 58.6±12.7; and kidney disease domain was 69.3±9.8. Analysis of Spearman correlation showed that the levels of intact parathyroid hormone significantly affect the physical health domain (p=0.027). Intact parathyroid hormone levels did not significantly affect the mental health domain and kidney disease domain (p > 0.05).

Kata Kunci : Penyakit ginjal kronis, hemodialisis, hormon paratiroid intak, kalsium karbonat, kualitas hidup, KDQOL-SF