Latar Belakang. Penyebab utama komplikasi pada diabetes mellitus adalah adanya kondisi stres oksidatif karena peningkatan reactive oxygen species (ROS). Peningkatan ROS tersebut salah satunya dipicu karena peningkatan advanced glycation end-products (AGE) yang berikatan dengan reseptornya (RAGE). Akibat dari peningkatan ROS akan menyebabkan peroksidasi pada lipid di membran sel dan menginduksi peningkatan malondialdehid (MDA). Tujuan penelitian ini adalah untuk mengevaluasi manfaat latihan fisik dalam mencegah komplikasi pada ginjal akibat hiperglikemia. Metode. Penelitian ini merupakan eksperimen murni dengan rancangan post test only group design. Subjek penelitian adalah 10 ekor tikus galur Sprague dawley jantan, yang diinduksi streptozotocin (STZ) dosis 35 mg/kgBB. Subjek dibagi dua kelompok yaitu, kelompok STZ dan kelompok STZ dengan latihan fisik. Latihan fisik diberikan selama 9 minggu menggunakan treadmill, frekuensi 5x/minggu, intensitas moderat, kemiringan 0º, kecepatan dan durasi ditingkatkan secara bertahap. Hasil. Latihan fisik teratur dan terukur berpengaruh terhadap prosentase penurunan gula darah puasa (p=0,048) dan ekspresi RAGE di glomerolus (p=0,003), namun kurang berpengaruh terhadap kadar MDA ginjal (p=0,767). Kesimpulan. Latihan fisik teratur dan terukur dapat menurunkan kadar GDP serta mampu mengurangi ekspresi RAGE di glomerolus.

Background. The main cause of complications in diabetes mellitus is a condition of oxidative stress due to increased reactive oxygen species (ROS). The increase in ROS can be triggered by the increase in advanced glycation end-products (AGE), which binds to its receptor (RAGE). The result of increased ROS will lead to lipid peroxidation in cell membranes and induce particular increase in malondialdehyde (MDA). The objective of this study was to evaluate the benefits of physical exercise in preventing complications of the kidney caused by hyperglycemia. Methods. This study was a pure experimental research with post-test only group design. Subjects were 10 male Sprague Dawley rats induced with 35 mg/kg dose of streptozotocin (STZ). The subjects were divided into two groups, i.e. the STZ group and STZ group with physical exercise. Physical exercise was given in 9 weeks using a treadmill, in 5 days of exercise/week, moderate intensity, 0 degree of tilt, gradually increased speed and duration. Results. Regular and measurable physical exercise can decrease the blood glucose level (0,048) and reduce the RAGE expression in glomerulus (0,003) but increase MDA level in kidney (0,767). Conclusion. Regular and measurable physical exercise can decrease the blood glucose level and reduce the RAGE expression in glomerolus.

Kata Kunci : : Diabetes mellitus, streptozotocin, latihan fisik, gula darah puasa, ekspresi RAGE, kadar MDA ginjal.